On a recent episode of The Rubin Report, host Dave Rubin and his co-hosts Dr. Drew Pinsky and Sage Steele turned their attention to a growing concern playing out in plain sight across red carpets and television screens: the visible physical toll that GLP-1 treatments appear to be taking on some of Hollywood’s most recognizable faces.
The conversation began when Rubin brought up Kelly Osbourne, noting that her changed appearance had become impossible to ignore. “At some point does someone have to say something to Kelly Osbourne,” he said. “I know there’s a series of them, so I don’t even mean to pick on her, but when you see these celebrities get up there, it doesn’t take, I don’t have to have all of the medical history that you have to know that something is not right about this.”
Dr. Drew responded by framing what he was observing as a medical pattern, not simply a cosmetic one. “It’s a new kind of eating disorder, right? And one of the main features of disturbed eating is loss of muscle mass. And you can see it.”
He went on to outline the broader risks he believes are being overlooked in conversations about GLP-1 treatment. “Not only is this an unhealthy way to lose weight, not only do you go above your baseline when you go off the medicine. So doctors are saying you got to be on it the rest of your life,” he said.
Drew continued: “That is a dangerous statement whenever doctors say that about medicines that are new especially. We’re seeing bowel obstructions. We’re seeing sepsis. We’re seeing gastroparesis. We’re seeing just tons of very serious medical problems that are not being sort of brought into the conversation of the risk-reward associated with these medicines. They’re not bad medicines. It’s just the risk-reward is not being properly analyzed for every given case.”
The second celebrity name to come up was Ryan Seacrest. Sage Steele shared that he had worked with Seacrest at a New Year’s Eve broadcast on ABC and had a personal connection to seeing him again recently.
Steele stated, “I always liked him and I worked with him once at a New Year’s event that we were on TV on ABC together in 2018 or something. He’s lovely. He was so kind and I saw him the other day and I got scared because he’s so thin.”
Dr. Drew again identified what he was describing through a clinical lens. “Whenever you see sunken and particularly the temporal, you see temporal muscle loss, that is a disturbed eating situation.”
